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KBSE
1995
IEEE
15 years 4 months ago
A Transformation System for Interactive Reformulation of Design Optimization Strategies
Numerical design optimization algorithms are highly sensitive to the particular formulation of the optimization problems they are given. The formulation of the search space, the o...
Thomas Ellman, John Keane, Takahiro Murata, Mark S...
BMCBI
2008
130views more  BMCBI 2008»
15 years 27 days ago
A database of phylogenetically atypical genes in archaeal and bacterial genomes, identified using the DarkHorse algorithm
Background: The process of horizontal gene transfer (HGT) is believed to be widespread in Bacteria and Archaea, but little comparative data is available addressing its occurrence ...
Sheila Podell, Terry Gaasterland, Eric E. Allen
98
Voted
BMCBI
2008
130views more  BMCBI 2008»
15 years 27 days ago
FAF-Drugs2: Free ADME/tox filtering tool to assist drug discovery and chemical biology projects
Background: Drug discovery and chemical biology are exceedingly complex and demanding enterprises. In recent years there are been increasing awareness about the importance of pred...
David Lagorce, Olivier Sperandio, Hervé Gal...
85
Voted
BMCBI
2006
101views more  BMCBI 2006»
15 years 25 days ago
SuperMimic - Fitting peptide mimetics into protein structures
Background: Various experimental techniques yield peptides that are biologically active but have unfavourable pharmacological properties. The design of structurally similar organi...
Andrean Goede, Elke Michalsky, Ulrike Schmidt, Rob...
BMCBI
2005
159views more  BMCBI 2005»
15 years 21 days ago
Columba: an integrated database of proteins, structures, and annotations
Background: Structural and functional research often requires the computation of sets of protein structures based on certain properties of the proteins, such as sequence features,...
Silke Trißl, Kristian Rother, Heiko Mül...