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BMCBI
2008
125views more  BMCBI 2008»
14 years 12 months ago
Exploration and visualization of gene expression with neuroanatomy in the adult mouse brain
Background: Spatially mapped large scale gene expression databases enable quantitative comparison of data measurements across genes, anatomy, and phenotype. In most ongoing effort...
Christopher Lau, Lydia Ng, Carol Thompson, Sayan D...
BMCBI
2006
130views more  BMCBI 2006»
14 years 11 months ago
CARMA: A platform for analyzing microarray datasets that incorporate replicate measures
Background: The incorporation of statistical models that account for experimental variability provides a necessary framework for the interpretation of microarray data. A robust ex...
Kevin A. Greer, Matthew R. McReynolds, Heddwen L. ...
BMCBI
2006
98views more  BMCBI 2006»
14 years 11 months ago
Optimised amino acid specific weighting factors for unbound protein docking
Background: One of the most challenging aspects of protein-protein docking is the inclusion of flexibility into the docking procedure. We developed a postfilter where the grid-rep...
Philipp Heuser, Dietmar Schomburg
BMCBI
2006
94views more  BMCBI 2006»
14 years 11 months ago
Simulation of microarray data with realistic characteristics
Background: Microarray technologies have become common tools in biological research. As a result, a need for effective computational methods for data analysis has emerged. Numerou...
Matti Nykter, Tommi Aho, Miika Ahdesmäki, Pek...
BMCBI
2007
94views more  BMCBI 2007»
14 years 11 months ago
A structural analysis of in vitro catalytic activities of hammerhead ribozymes
Background: Ribozymes are small catalytic RNAs that possess the dual functions of sequencespecific RNA recognition and site-specific cleavage. Trans-cleaving ribozymes can inhibit...
Yu Shao, Susan Wu, Chi Yu Chan, Jessie R. Klapper,...