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» Pfam: multiple sequence alignments and HMM-profiles of prote...
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BMCBI
2005
190views more  BMCBI 2005»
14 years 11 months ago
Species-specific analysis of protein sequence motifs using mutual information
Background: Protein sequence motifs are by definition short fragments of conserved amino acids, often associated with a specific function. Accordingly protein sequence profiles de...
Jan Hummel, Nima Keshvari, Wolfram Weckwerth, Joac...
BMCBI
2008
145views more  BMCBI 2008»
14 years 11 months ago
The contrasting properties of conservation and correlated phylogeny in protein functional residue prediction
Background: Amino acids responsible for structure, core function or specificity may be inferred from multiple protein sequence alignments where a limited set of residue types are ...
Jonathan R. Manning, Emily R. Jefferson, Geoffrey ...
COMAD
2008
15 years 1 months ago
REBMEC: Repeat Based Maximum Entropy Classifier for Biological Sequences
An important problem in biological data analysis is to predict the family of a newly discovered sequence like a protein or DNA sequence, using the collection of available sequence...
Pratibha Rani, Vikram Pudi
BMCBI
2005
75views more  BMCBI 2005»
14 years 11 months ago
Prediction of a common structural scaffold for proteasome lid, COP9-signalosome and eIF3 complexes
Background: The 'lid' subcomplex of the 26S proteasome and the COP9 signalosome (CSN complex) share a common architecture consisting of six subunits harbouring a so-call...
Hartmut Scheel, Kay Hofmann
98
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AB
2007
Springer
15 years 5 months ago
Manifestation and Exploitation of Invariants in Bioinformatics
Whenever a programmer writes a loop, or a mathematician does a proof by induction, an invariant is involved. The discovery and understanding of invariants often underlies problem s...
Limsoon Wong