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» Pfam: multiple sequence alignments and HMM-profiles of prote...
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BMCBI
2005
190views more  BMCBI 2005»
13 years 6 months ago
Species-specific analysis of protein sequence motifs using mutual information
Background: Protein sequence motifs are by definition short fragments of conserved amino acids, often associated with a specific function. Accordingly protein sequence profiles de...
Jan Hummel, Nima Keshvari, Wolfram Weckwerth, Joac...
BMCBI
2008
145views more  BMCBI 2008»
13 years 6 months ago
The contrasting properties of conservation and correlated phylogeny in protein functional residue prediction
Background: Amino acids responsible for structure, core function or specificity may be inferred from multiple protein sequence alignments where a limited set of residue types are ...
Jonathan R. Manning, Emily R. Jefferson, Geoffrey ...
COMAD
2008
13 years 7 months ago
REBMEC: Repeat Based Maximum Entropy Classifier for Biological Sequences
An important problem in biological data analysis is to predict the family of a newly discovered sequence like a protein or DNA sequence, using the collection of available sequence...
Pratibha Rani, Vikram Pudi
BMCBI
2005
75views more  BMCBI 2005»
13 years 6 months ago
Prediction of a common structural scaffold for proteasome lid, COP9-signalosome and eIF3 complexes
Background: The 'lid' subcomplex of the 26S proteasome and the COP9 signalosome (CSN complex) share a common architecture consisting of six subunits harbouring a so-call...
Hartmut Scheel, Kay Hofmann
AB
2007
Springer
14 years 13 days ago
Manifestation and Exploitation of Invariants in Bioinformatics
Whenever a programmer writes a loop, or a mathematician does a proof by induction, an invariant is involved. The discovery and understanding of invariants often underlies problem s...
Limsoon Wong