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BMCBI
2010
153views more  BMCBI 2010»
15 years 2 months ago
Analysis of substructural variation in families of enzymatic proteins with applications to protein function prediction
Background: Structural variations caused by a wide range of physico-chemical and biological sources directly influence the function of a protein. For enzymatic proteins, the struc...
Drew H. Bryant, Mark Moll, Brian Y. Chen, Viachesl...
BMCBI
2010
103views more  BMCBI 2010»
15 years 2 months ago
A method of predicting changes in human gene splicing induced by genetic variants in context of cis-acting elements
Background: Polymorphic variants and mutations disrupting canonical splicing isoforms are among the leading causes of human hereditary disorders. While there is a substantial evid...
Alexander G. Churbanov, Igor Vorechovsky, Chindo H...
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BMCBI
2010
165views more  BMCBI 2010»
15 years 2 months ago
Bayesian integrated modeling of expression data: a case study on RhoG
Background: DNA microarrays provide an efficient method for measuring activity of genes in parallel and even covering all the known transcripts of an organism on a single array. T...
Rashi Gupta, Dario Greco, Petri Auvinen, Elja Arja...
BMCBI
2010
129views more  BMCBI 2010»
15 years 2 months ago
LAITOR - Literature Assistant for Identification of Terms co-Occurrences and Relationships
Background: Biological knowledge is represented in scientific literature that often describes the function of genes/ proteins (bioentities) in terms of their interactions (biointe...
Adriano Barbosa-Silva, Theodoros G. Soldatos, Ivan...
BMCBI
2010
183views more  BMCBI 2010»
15 years 2 months ago
SING: Subgraph search In Non-homogeneous Graphs
Background: Finding the subgraphs of a graph database that are isomorphic to a given query graph has practical applications in several fields, from cheminformatics to image unders...
Raffaele Di Natale, Alfredo Ferro, Rosalba Giugno,...
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