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130
Voted
BMCBI
2010
15 years 2 months ago
2010
Background: Next-generation sequencing technologies allow researchers to obtain millions of sequence reads in a single experiment. One important use of the technology is the seque...
121
Voted
BMCBI
2010
15 years 2 months ago
2010
Background: Single nucleotide polymorphism (SNP) based association studies aim at identifying SNPs associated with phenotypes, for example, complex diseases. The associated SNPs m...
159
Voted
BMCBI
2010
15 years 2 months ago
2010
Background: Several diseases, many of which nowadays pandemic, consist of multifactorial pathologies. Paradigmatic examples come from the immune response to pathogens, in which ca...
119
Voted
BMCBI
2008
15 years 2 months ago
2008
Background: The rate of mRNA transcription is controlled by transcription factors that bind to specific DNA motifs in promoter regions upstream of protein coding genes. Recent res...
121
Voted
BMCBI
2008
15 years 2 months ago
2008
Background: Recent genomic scale survey of epigenetic states in the mammalian genomes has shown that promoters and enhancers are correlated with distinct chromatin signatures, pro...