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105
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BMCBI
2010
88views more  BMCBI 2010»
15 years 2 months ago
Robust probabilistic superposition and comparison of protein structures
Background: Protein structure comparison is a central issue in structural bioinformatics. The standard dissimilarity measure for protein structures is the root mean square deviati...
Martin Mechelke, Michael Habeck
133
Voted
BMCBI
2008
128views more  BMCBI 2008»
15 years 2 months ago
Pairwise covariance adds little to secondary structure prediction but improves the prediction of non-canonical local structure
Background: Amino acid sequence probability distributions, or profiles, have been used successfully to predict secondary structure and local structure in proteins. Profile models ...
Christopher Bystroff, Bobbie-Jo M. Webb-Robertson
112
Voted
BMCBI
2007
121views more  BMCBI 2007»
15 years 2 months ago
Predicting zinc binding at the proteome level
Background: Metalloproteins are proteins capable of binding one or more metal ions, which may be required for their biological function, for regulation of their activities or for ...
Andrea Passerini, Claudia Andreini, Sauro Menchett...
108
Voted
BMCBI
2008
105views more  BMCBI 2008»
15 years 2 months ago
Using the longest significance run to estimate region-specific p-values in genetic association mapping studies
Background: Association testing is a powerful tool for identifying disease susceptibility genes underlying complex diseases. Technological advances have yielded a dramatic increas...
Ie-Bin Lian, Yi-Hsien Lin, Ying-Chao Lin, Hsin-Cho...
98
Voted
BMCBI
2007
91views more  BMCBI 2007»
15 years 2 months ago
A machine learning approach for the identification of odorant binding proteins from sequence-derived properties
Background: Odorant binding proteins (OBPs) are believed to shuttle odorants from the environment to the underlying odorant receptors, for which they could potentially serve as od...
Ganesan Pugalenthi, E. Ke Tang, Ponnuthurai N. Sug...
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