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BMCBI
2004
88views more  BMCBI 2004»
15 years 1 months ago
Coronavirus 3CLpro proteinase cleavage sites: Possible relevance to SARS virus pathology
Background: Despite the passing of more than a year since the first outbreak of Severe Acute Respiratory Syndrome (SARS), efficient counter-measures are still few and many believe...
Lars Kiemer, Ole Lund, Søren Brunak, Nikola...
BMCBI
2010
126views more  BMCBI 2010»
14 years 11 months ago
PETALS: Proteomic Evaluation and Topological Analysis of a mutated Locus' Signaling
Background: Colon cancer is driven by mutations in a number of genes, the most notorious of which is Apc. Though much of Apc's signaling has been mechanistically identified o...
Gürkan Bebek, Vishal Patel, Mark R. Chance
AB
2008
Springer
15 years 8 months ago
An Algorithm for Qualitative Simulation of Gene Regulatory Networks with Steep Sigmoidal Response Functions
A specific class of ODEs has been shown to be adequate to describe the essential features of the complex dynamics of Gene-Regulatory Networks (GRN). But, the effective exploitatio...
Liliana Ironi, Luigi Panzeri, Erik Plahte
SC
2009
ACM
15 years 6 months ago
A framework for core-level modeling and design of reconfigurable computing algorithms
Reconfigurable computing (RC) is rapidly becoming a vital technology for many applications, from high-performance computing to embedded systems. The inherent advantages of custom-...
Gongyu Wang, Greg Stitt, Herman Lam, Alan D. Georg...
BMCBI
2008
106views more  BMCBI 2008»
15 years 2 months ago
Identification of hot-spot residues in protein-protein interactions by computational docking
Background: The study of protein-protein interactions is becoming increasingly important for biotechnological and therapeutic reasons. We can define two major areas therein: the s...
Solène Grosdidier, Juan Fernández-Re...