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BMCBI
2006
2006
Searching for interpretable rules for disease mutations: a simulated annealing bump hunting strategy
14 years 10 months ago
Background: Understanding how amino acid substitutions affect protein functions is critical for the study of proteins and their implications in diseases. Although methods have bee...
BMCBI
2007
14 years 10 months ago
2007
Background: As the number of fully sequenced genome increases, the need is greater for bioinformatics to predict or annotate genes of a newly sequenced genome. Ever since Eisenber...
BMCBI
2005
14 years 10 months ago
2005
Background: The large amount of completely sequenced genomes allows genomic context analysis to predict reliable functional associations between prokaryotic proteins. Major method...
BMCBI
2005
14 years 10 months ago
2005
Background: The majority of residues in protein structures are involved in the formation of helices and -strands. These distinctive secondary structure patterns can be used to rep...
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BMCBI
2011
14 years 5 months ago
2011
Background: Most predictive methods currently available for the identification of protein secretion mechanisms have focused on classically secreted proteins. In fact, only two met...