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BMCBI
2006
198views more  BMCBI 2006»
15 years 1 months ago
Gene selection and classification of microarray data using random forest
Background: Selection of relevant genes for sample classification is a common task in most gene expression studies, where researchers try to identify the smallest possible set of ...
Ramón Díaz-Uriarte, Sara Alvarez de ...
BIOINFORMATICS
2006
129views more  BIOINFORMATICS 2006»
15 years 1 months ago
Predicting methylation status of CpG islands in the human brain
Motivation: Over 50% of human genes contain CpG islands in their 5'-regions. Methylation patterns of CpG islands are involved in tissue-specific gene expression and regulatio...
Fang Fang, Shicai Fan, Xuegong Zhang, Michael Q. Z...
RECOMB
2010
Springer
15 years 3 months ago
Algorithms for Detecting Significantly Mutated Pathways in Cancer
Abstract. Recent genome sequencing studies have shown that the somatic mutations that drive cancer development are distributed across a large number of genes. This mutational heter...
Fabio Vandin, Eli Upfal, Benjamin J. Raphael
BIOINFORMATICS
2005
134views more  BIOINFORMATICS 2005»
15 years 1 months ago
Outcome signature genes in breast cancer: is there a unique set?
Motivation: direct bearing whose expres Sorlie et al., 2 gene sets is a diseases (Lossos et al., 2004; Miklos and Maleszka, 2004), and the variables that could account questions i...
Liat Ein-Dor, Itai Kela, Gad Getz, David Givol, Ey...
BMCBI
2011
14 years 5 months ago
Linear and non-linear dependencies between copy number aberrations and mRNA expression reveal distinct molecular pathways in Bre
Background: Elucidating the exact relationship between gene copy number and expression would enable identification of regulatory mechanisms of abnormal gene expression and biologi...
Hiroko K. Solvang, Ole Christian Lingjærde, ...