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» Predicting protein function from domain content
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BMCBI
2004
111views more  BMCBI 2004»
14 years 9 months ago
The Hotdog fold: wrapping up a superfamily of thioesterases and dehydratases
Background: The Hotdog fold was initially identified in the structure of Escherichia coli FabA and subsequently in 4-hydroxybenzoyl-CoA thioesterase from Pseudomonas sp. strain CB...
Shane C. Dillon, Alex Bateman
ISMB
1997
14 years 10 months ago
Prediction of Enzyme Classification from Protein Sequence without the Use of Sequence Similarity
1 W’edescribe a novel approach for predicting the function of a protein from its amino-acid sequence. Given features that can be computedfrom the amino-acid sequence in a straigh...
Marie desJardins, Peter D. Karp, Markus Krummenack...
CSB
2005
IEEE
117views Bioinformatics» more  CSB 2005»
15 years 3 months ago
Protein Structure Prediction Using Physical-Based Global Optimization and Knowledge-Guided Fragment Packing
We describe a new method to predict the tertiary structure of new-fold proteins. Our two-phase approach combines the knowledge-based fragmentpacking with the minimization of a phy...
Jinhui Ding, Elizabeth Eskow, Nelson L. Max, Silvi...
BIBE
2005
IEEE
154views Bioinformatics» more  BIBE 2005»
15 years 3 months ago
Effective Pre-Processing Strategies for Functional Clustering of a Protein-Protein Interactions Network
In this article we present novel preprocessing techniques, based on topological measures of the network, to identify clusters of proteins from Protein-protein interaction (PPI) ne...
Duygu Ucar, Srinivasan Parthasarathy, Sitaram Asur...
NAR
1998
86views more  NAR 1998»
14 years 9 months ago
Pfam: multiple sequence alignments and HMM-profiles of protein domains
Pfam contains multiple alignments and hidden Markov model based profiles (HMM-profiles) of complete protein domains. The definition of domain boundaries, family members and alignm...
Erik L. L. Sonnhammer, Sean R. Eddy, Ewan Birney, ...