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» Predicting protein function from domain content
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BMCBI
2007
107views more  BMCBI 2007»
15 years 5 months ago
Reuse of structural domain-domain interactions in protein networks
Background: Protein interactions are thought to be largely mediated by interactions between structural domains. Databases such as iPfam relate interactions in protein structures t...
Benjamin Schuster-Böckler, Alex Bateman
BMCBI
2008
123views more  BMCBI 2008»
15 years 5 months ago
A tree-based conservation scoring method for short linear motifs in multiple alignments of protein sequences
Background: The structure of many eukaryotic cell regulatory proteins is highly modular. They are assembled from globular domains, segments of natively disordered polypeptides and...
Claudia Chica, Alberto Labarga, Cathryn M. Gould, ...
BIBM
2008
IEEE
217views Bioinformatics» more  BIBM 2008»
15 years 11 months ago
Combining Hierarchical Inference in Ontologies with Heterogeneous Data Sources Improves Gene Function Prediction
The study of gene function is critical in various genomic and proteomic fields. Due to the availability of tremendous amounts of different types of protein data, integrating thes...
Xiaoyu Jiang, Naoki Nariai, Martin Steffen, Simon ...
ISMB
1996
15 years 6 months ago
A Knowledge-Based Method for Protein Structure Refinement and Prediction
The native conformation of a protein, in a given environment, is determined entirely by the various interatomic interactions dictated by the amino acid sequence (1-3). We describe...
Shankar Subramaniam, David K. Tcheng, James M. Fen...
157
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APBC
2003
134views Bioinformatics» more  APBC 2003»
15 years 6 months ago
A Framework for Improving Protein Structure Predictions by Teamwork
Predicting the three dimensional structure of proteins is a difficult task. In the last years several approaches have been proposed for performing this task taking into account d...
Luigi Palopoli, Giorgio Terracina