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» Predicting protein function from domain content
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ICML
2008
IEEE
16 years 6 months ago
Sequence kernels for predicting protein essentiality
The problem of identifying the minimal gene set required to sustain life is of crucial importance in understanding cellular mechanisms and designing therapeutic drugs. This work d...
Cyril Allauzen, Mehryar Mohri, Ameet Talwalkar
BMCBI
2010
109views more  BMCBI 2010»
15 years 5 months ago
Pripper: prediction of caspase cleavage sites from whole proteomes
Background: Caspases are a family of proteases that have central functions in programmed cell death (apoptosis) and inflammation. Caspases mediate their effects through aspartate-...
Mirva Piippo, Niina Lietzén, Olli Nevalaine...
KDD
2003
ACM
142views Data Mining» more  KDD 2003»
16 years 5 months ago
Frequent-subsequence-based prediction of outer membrane proteins
A number of medically important disease-causing bacteria (collectively called Gram-negative bacteria) are noted for the extra "outer" membrane that surrounds their cell....
Rong She, Fei Chen 0002, Ke Wang, Martin Ester, Je...
148
Voted
BMCBI
2004
96views more  BMCBI 2004»
15 years 5 months ago
A hybrid clustering approach to recognition of protein families in 114 microbial genomes
Background: Grouping proteins into sequence-based clusters is a fundamental step in many bioinformatic analyses (e.g., homology-based prediction of structure or function). Standar...
Timothy J. Harlow, J. Peter Gogarten, Mark A. Raga...
152
Voted
BMCBI
2010
82views more  BMCBI 2010»
15 years 5 months ago
Predicting the network of substrate-enzyme-product triads by combining compound similarity and functional domain composition
Background: Metabolic pathway is a highly regulated network consisting of many metabolic reactions involving substrates, enzymes, and products, where substrates can be transformed...
Lei Chen, Kai-Yan Feng, Yu-Dong Cai, Kuo-Chen Chou...