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» Predicting protein function from domain content
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BMCBI
2008
82views more  BMCBI 2008»
15 years 5 months ago
Studying the functional conservation of cis-regulatory modules and their transcriptional output
Background: Cis-regulatory modules (CRMs) are distinct, genomic regions surrounding the target gene that can independently activate the promoter to drive transcription. The activa...
Denis C. Bauer, Timothy L. Bailey
BMCBI
2007
144views more  BMCBI 2007»
15 years 5 months ago
Motif kernel generated by genetic programming improves remote homology and fold detection
Background: Protein remote homology detection is a central problem in computational biology. Most recent methods train support vector machines to discriminate between related and ...
Tony Håndstad, Arne J. H. Hestnes, Pål...
160
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AAAI
2012
13 years 8 months ago
Semi-Supervised Kernel Matching for Domain Adaptation
In this paper, we propose a semi-supervised kernel matching method to address domain adaptation problems where the source distribution substantially differs from the target distri...
Min Xiao, Yuhong Guo
BMCBI
2007
117views more  BMCBI 2007»
15 years 5 months ago
Supervised multivariate analysis of sequence groups to identify specificity determining residues
Background: Proteins that evolve from a common ancestor can change functionality over time, and it is important to be able identify residues that cause this change. In this paper ...
Iain M. Wallace, Desmond G. Higgins
BMCBI
2010
103views more  BMCBI 2010»
15 years 5 months ago
PostMod: sequence based prediction of kinase-specific phosphorylation sites with indirect relationship
Background: Post-translational modifications (PTMs) have a key role in regulating cell functions. Consequently, identification of PTM sites has a significant impact on understandi...
Inkyung Jung, Akihisa Matsuyama, Minoru Yoshida, D...