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» Predicting protein functions with message passing algorithms
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81
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BMCBI
2008
114views more  BMCBI 2008»
14 years 9 months ago
Combining classifiers for improved classification of proteins from sequence or structure
Background: Predicting a protein's structural or functional class from its amino acid sequence or structure is a fundamental problem in computational biology. Recently, there...
Iain Melvin, Jason Weston, Christina S. Leslie, Wi...
BMCBI
2006
108views more  BMCBI 2006»
14 years 9 months ago
Gene function classification using Bayesian models with hierarchy-based priors
We investigate the application of hierarchical classification schemes to the annotation of gene function based on several characteristics of protein sequences including phylogenic ...
Babak Shahbaba, Radford M. Neal
BMCBI
2010
121views more  BMCBI 2010»
14 years 9 months ago
Knowledge-based annotation of small molecule binding sites in proteins
Background: The study of protein-small molecule interactions is vital for understanding protein function and for practical applications in drug discovery. To benefit from the rapi...
Ratna R. Thangudu, Manoj Tyagi, Benjamin A. Shoema...
93
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WWW
2009
ACM
15 years 10 months ago
Matchbox: large scale online bayesian recommendations
We present a probabilistic model for generating personalised recommendations of items to users of a web service. The Matchbox system makes use of content information in the form o...
David H. Stern, Ralf Herbrich, Thore Graepel
BCB
2010
140views Bioinformatics» more  BCB 2010»
14 years 4 months ago
Guiding belief propagation using domain knowledge for protein-structure determination
A major bottleneck in high-throughput protein crystallography is producing protein-structure models from an electrondensity map. In previous work, we developed Acmi, a probabilist...
Ameet Soni, Craig A. Bingman, Jude W. Shavlik