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BMCBI
2008
84views more  BMCBI 2008»
14 years 12 months ago
Prediction of specificity-determining residues for small-molecule kinase inhibitors
Background: Designing small-molecule kinase inhibitors with desirable selectivity profiles is a major challenge in drug discovery. A high-throughput screen for inhibitors of a giv...
Daniel R. Caffrey, Elizabeth A. Lunney, Deborah J....
BMCBI
2004
205views more  BMCBI 2004»
14 years 11 months ago
A combinational feature selection and ensemble neural network method for classification of gene expression data
Background: Microarray experiments are becoming a powerful tool for clinical diagnosis, as they have the potential to discover gene expression patterns that are characteristic for...
Bing Liu, Qinghua Cui, Tianzi Jiang, Songde Ma
CIBCB
2007
IEEE
15 years 3 months ago
Genetic Regulatory Network Modeling Using Network Component Analysis and Fuzzy Clustering
Gene regulatory network model is the most widely used mechanism to model and predict the behavior of living organisms. Network Component Analysis (NCA) as an emerging issue for unc...
Fatemeh Bakouie, Mohammad Hassan Moradi
BMCBI
2010
125views more  BMCBI 2010»
14 years 6 months ago
ProbFAST: Probabilistic Functional Analysis System Tool
Background: The post-genomic era has brought new challenges regarding the understanding of the organization and function of the human genome. Many of these challenges are centered...
Israel T. da Silva, Ricardo Z. N. Vêncio, Th...
CIBCB
2005
IEEE
15 years 5 months ago
Artificial Neural Network Analysis of DNA Microarray-based Prostate Cancer Recurrence
— DNA microarray-based gene expression profiles have been established for a variety of adult cancers. This paper addresses application of an artificial neural network (ANN) wit...
Leif E. Peterson, Mustafa Ozen, Halime Erdem, Andr...