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» Prediction and uncertainty in the analysis of gene expressio...
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BMCBI
2006
130views more  BMCBI 2006»
14 years 10 months ago
An accurate and interpretable model for siRNA efficacy prediction
Background: The use of exogenous small interfering RNAs (siRNAs) for gene silencing has quickly become a widespread molecular tool providing a powerful means for gene functional s...
Jean-Philippe Vert, Nicolas Foveau, Christian Laja...
BMCBI
2007
113views more  BMCBI 2007»
14 years 10 months ago
CoryneRegNet 4.0 - A reference database for corynebacterial gene regulatory networks
Background: Detailed information on DNA-binding transcription factors (the key players in the regulation of gene expression) and on transcriptional regulatory interactions of micr...
Jan Baumbach
99
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BMCBI
2006
122views more  BMCBI 2006»
14 years 10 months ago
A multivariate prediction model for microarray cross-hybridization
Background: Expression microarray analysis is one of the most popular molecular diagnostic techniques in the post-genomic era. However, this technique faces the fundamental proble...
Yian A. Chen, Cheng-Chung Chou, Xinghua Lu, Elizab...
104
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BIB
2007
59views more  BIB 2007»
14 years 10 months ago
Statistically designing microarrays and microarray experiments to enhance sensitivity and specificity
Gene expression signatures from microarray experiments promise to provide important prognostic tools for predicting disease outcome or response to treatment. A number of microarra...
Jason C. Hsu, Jane Chang, Tao Wang, Eiríkur...
101
Voted
BMCBI
2008
135views more  BMCBI 2008»
14 years 10 months ago
Using Generalized Procrustes Analysis (GPA) for normalization of cDNA microarray data
Background: Normalization is essential in dual-labelled microarray data analysis to remove nonbiological variations and systematic biases. Many normalization methods have been use...
Huiling Xiong, Dapeng Zhang, Christopher J. Martyn...