Background: An important aspect of protein design is the ability to predict changes in protein thermostability arising from single- or multi-site mutations. Protein thermostabilit...
Despite popular belief, boosting algorithms and related coordinate descent methods are prone to overfitting. We derive modifications to AdaBoost and related gradient-based coordin...
Background: Support Vector Machines (SVMs) ? using a variety of string kernels ? have been successfully applied to biological sequence classification problems. While SVMs achieve ...
Gradient-based numerical optimization of complex engineering designs offers the promise of rapidly producing better designs. However, such methods generally assume that the object...
Adoption of advanced automated SE (ASE) tools would be favored if a business case could be made that these tools are more valuable than alternate methods. In theory, software pred...
Tim Menzies, Oussama El-Rawas, Jairus Hihn, Martin...