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» Prediction of indirect interactions in proteins
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BMCBI
2008
118views more  BMCBI 2008»
15 years 2 months ago
Drug interaction prediction using ontology-driven hypothetical assertion framework for pathway generation followed by numerical
Background: In accordance with the increasing amount of information concerning individual differences in drug response and molecular interaction, the role of in silico prediction ...
Takeshi Arikuma, Sumi Yoshikawa, Ryuzo Azuma, Kent...
BIBM
2010
IEEE
158views Bioinformatics» more  BIBM 2010»
14 years 12 months ago
Protein-protein interaction prediction via Collective Matrix Factorization
Abstract--Protein-protein interactions (PPI) play an important role in cellular processes and metabolic processes within a cell. An important task is to determine the existence of ...
Qian Xu, Evan Wei Xiang, Qiang Yang
BIOINFORMATICS
2006
101views more  BIOINFORMATICS 2006»
15 years 1 months ago
A lock-and-key model for protein-protein interactions
Motivation: Protein-protein interaction networks are one of the major post-genomic data sources available to molecular biologists. They provide a comprehensive view of the global ...
Julie L. Morrison, Rainer Breitling, Desmond J. Hi...
BMCBI
2007
145views more  BMCBI 2007»
15 years 2 months ago
Genome bioinformatic analysis of nonsynonymous SNPs
Background: Genome-wide association studies of common diseases for common, low penetrance causal variants are underway. A proportion of these will alter protein sequences, the mos...
David F. Burke, Catherine L. Worth, Eva-Maria Prie...
BMCBI
2005
116views more  BMCBI 2005»
15 years 1 months ago
SuperLigands - a database of ligand structures derived from the Protein Data Bank
Background: Currently, the PDB contains approximately 29,000 protein structures comprising over 70,000 experimentally determined three-dimensional structures of over 5,000 differe...
Elke Michalsky, Mathias Dunkel, Andrean Goede, Rob...