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BMCBI
2008
95views more  BMCBI 2008»
15 years 1 months ago
Methodology capture: discriminating between the "best" and the rest of community practice
Background: The methodologies we use both enable and help define our research. However, as experimental complexity has increased the choice of appropriate methodologies has become...
James M. Eales, John W. Pinney, Robert D. Stevens,...
BMCBI
2008
99views more  BMCBI 2008»
15 years 1 months ago
A new real-time PCR method to overcome significant quantitative inaccuracy due to slight amplification inhibition
Background: Real-time PCR analysis is a sensitive DNA quantification technique that has recently gained considerable attention in biotechnology, microbiology and molecular diagnos...
Michele Guescini, Davide Sisti, Marco B. L. Rocchi...
BMCBI
2007
111views more  BMCBI 2007»
15 years 1 months ago
Novel definition files for human GeneChips based on GeneAnnot
Background: Improvements in genome sequence annotation revealed discrepancies in the original probeset/gene assignment in Affymetrix microarray and the existence of differences be...
Francesco Ferrari, Stefania Bortoluzzi, Alessandro...
BMCBI
2007
115views more  BMCBI 2007»
15 years 1 months ago
Comparing sequences without using alignments: application to HIV/SIV subtyping
Background: In general, the construction of trees is based on sequence alignments. This procedure, however, leads to loss of informationwhen parts of sequence alignments (for inst...
Gilles Didier, Laurent Debomy, Maude Pupin, Ming Z...
BMCBI
2008
137views more  BMCBI 2008»
15 years 1 months ago
VennMaster: Area-proportional Euler diagrams for functional GO analysis of microarrays
Background: Microarray experiments generate vast amounts of data. The functional context of differentially expressed genes can be assessed by querying the Gene Ontology (GO) datab...
Hans A. Kestler, André Müller, Johann ...