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119
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BMCBI
2006
161views more  BMCBI 2006»
15 years 18 days ago
A novel approach to phylogenetic tree construction using stochastic optimization and clustering
Background: The problem of inferring the evolutionary history and constructing the phylogenetic tree with high performance has become one of the major problems in computational bi...
Ling Qin, Yixin Chen, Yi Pan, Ling Chen
BMCBI
2006
95views more  BMCBI 2006»
15 years 18 days ago
Estimate haplotype frequencies in pedigrees
Background: Haplotype analysis has gained increasing attention in the context of association studies of disease genes and drug responsivities over the last years. The potential us...
Qiangfeng Zhang, YuZhong Zhao, Guoliang Chen, Yun ...
114
Voted
BMCBI
2006
150views more  BMCBI 2006»
15 years 18 days ago
Predicting protein subcellular locations using hierarchical ensemble of Bayesian classifiers based on Markov chains
Background: The subcellular location of a protein is closely related to its function. It would be worthwhile to develop a method to predict the subcellular location for a given pr...
Alla Bulashevska, Roland Eils
112
Voted
BMCBI
2006
94views more  BMCBI 2006»
15 years 18 days ago
Noise-injected neural networks show promise for use on small-sample expression data
Background: Overfitting the data is a salient issue for classifier design in small-sample settings. This is why selecting a classifier from a constrained family of classifiers, on...
Jianping Hua, James Lowey, Zixiang Xiong, Edward R...
120
Voted
BMCBI
2006
125views more  BMCBI 2006»
15 years 18 days ago
Development of an open source laboratory information management system for 2-D gel electrophoresis-based proteomics workflow
Background: In the post-genome era, most research scientists working in the field of proteomics are confronted with difficulties in management of large volumes of data, which they...
Hiraku Morisawa, Mikako Hirota, Tosifusa Toda
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