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» Protein homology detection using string alignment kernels
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BIOINFORMATICS
2004
46views more  BIOINFORMATICS 2004»
14 years 10 months ago
Protein homology detection using string alignment kernels
Hiroto Saigo, Jean-Philippe Vert, Nobuhisa Ueda, T...
CIBCB
2005
IEEE
15 years 4 months ago
The Homology Kernel: A Biologically Motivated Sequence Embedding into Euclidean Space
— Part of the challenge of modeling protein sequences is their discrete nature. Many of the most powerful statistical and learning techniques are applicable to points in a Euclid...
Eleazar Eskin, Sagi Snir
ICPR
2008
IEEE
16 years 3 days ago
Fast protein homology and fold detection with sparse spatial sample kernels
In this work we present a new string similarity feature, the sparse spatial sample (SSS). An SSS is a set of short substrings at specific spatial displacements contained in the or...
Pai-Hsi Huang, Pavel P. Kuksa, Vladimir Pavlovic
95
Voted
BIOINFORMATICS
2005
140views more  BIOINFORMATICS 2005»
14 years 10 months ago
Profile-based direct kernels for remote homology detection and fold recognition
Motivation: Remote homology detection between protein sequences is a central problem in computational biology. Supervised learning algorithms based on support vector machines are ...
Huzefa Rangwala, George Karypis
89
Voted
BMCBI
2006
120views more  BMCBI 2006»
14 years 11 months ago
Optimizing amino acid substitution matrices with a local alignment kernel
Background: Detecting remote homologies by direct comparison of protein sequences remains a challenging task. We had previously developed a similarity score between sequences, cal...
Hiroto Saigo, Jean-Philippe Vert, Tatsuya Akutsu