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BMCBI
2008
99views more  BMCBI 2008»
14 years 9 months ago
A new real-time PCR method to overcome significant quantitative inaccuracy due to slight amplification inhibition
Background: Real-time PCR analysis is a sensitive DNA quantification technique that has recently gained considerable attention in biotechnology, microbiology and molecular diagnos...
Michele Guescini, Davide Sisti, Marco B. L. Rocchi...
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BMCBI
2008
129views more  BMCBI 2008»
14 years 9 months ago
Triad pattern algorithm for predicting strong promoter candidates in bacterial genomes
Background: Bacterial promoters, which increase the efficiency of gene expression, differ from other promoters by several characteristics. This difference, not yet widely exploite...
Michael Dekhtyar, Amelie Morin, Vehary Sakanyan
BMCBI
2007
120views more  BMCBI 2007»
14 years 9 months ago
Re-sampling strategy to improve the estimation of number of null hypotheses in FDR control under strong correlation structures
Background: When conducting multiple hypothesis tests, it is important to control the number of false positives, or the False Discovery Rate (FDR). However, there is a tradeoff be...
Xin Lu, David L. Perkins
BMCBI
2008
107views more  BMCBI 2008»
14 years 9 months ago
A machine learning approach to explore the spectra intensity pattern of peptides using tandem mass spectrometry data
Background: A better understanding of the mechanisms involved in gas-phase fragmentation of peptides is essential for the development of more reliable algorithms for high-throughp...
Cong Zhou, Lucas D. Bowler, Jianfeng Feng
BMCBI
2010
105views more  BMCBI 2010»
14 years 9 months ago
Predicting phenotypic traits of prokaryotes from protein domain frequencies
Background: Establishing the relationship between an organism's genome sequence and its phenotype is a fundamental challenge that remains largely unsolved. Accurately predict...
Thomas Lingner, Stefanie Mühlhausen, Toni Gab...