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BIBE
2010
IEEE
144views Bioinformatics» more  BIBE 2010»
14 years 10 months ago
Knowledge-Guided Docking of Flexible Ligands to SH2 Domain Proteins
Studies of interactions between protein domains and ligands are important in many aspects such as cellular signaling and regulation. In this work, we applied a three-stage knowledg...
Haiyun Lu, Shamima Banu Bte Sm Rashid, Hao Li, Wee...
GECCO
2008
Springer
143views Optimization» more  GECCO 2008»
14 years 10 months ago
Application domain study of evolutionary algorithms in optimization problems
This paper deals with the problem of comparing and testing evolutionary algorithms, that is, the benchmarking problem, from an analysis point of view. A practical study of the app...
Pilar Caamaño, Francisco Bellas, José...
BMCBI
2010
143views more  BMCBI 2010»
14 years 9 months ago
An efficient biological pathway layout algorithm combining grid-layout and spring embedder for complicated cellular location inf
Background: Graph drawing is one of the important techniques for understanding biological regulations in a cell or among cells at the pathway level. Among many available layout al...
Kaname Kojima, Masao Nagasaki, Satoru Miyano
BMCBI
2007
99views more  BMCBI 2007»
14 years 9 months ago
The Deuterator: software for the determination of backbone amide deuterium levels from H/D exchange MS data
Background: The combination of mass spectrometry and solution phase amide hydrogen/deuterium exchange (H/D exchange) experiments is an effective method for characterizing protein ...
B. D. Pascal, M. J. Chalmers, S. A. Busby, C. C. M...
BMCBI
2010
151views more  BMCBI 2010»
14 years 9 months ago
Using diffusion distances for flexible molecular shape comparison
Background: Many molecules are flexible and undergo significant shape deformation as part of their function, and yet most existing molecular shape comparison (MSC) methods treat t...
Yu-Shen Liu, Qi Li, Guo-Qin Zheng, Karthik Ramani,...