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» Reaction Motifs in Metabolic Networks
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BMCBI
2006
125views more  BMCBI 2006»
14 years 9 months ago
Algebraic comparison of metabolic networks, phylogenetic inference, and metabolic innovation
Metabolic networks are naturally represented as directed hypergraphs in such a way that metabolites are nodes and enzyme-catalyzed reactions form (hyper)edges. The familiar operat...
Christian V. Forst, Christoph Flamm, Ivo L. Hofack...
JCB
2008
96views more  JCB 2008»
14 years 9 months ago
Computing Knock-Out Strategies in Metabolic Networks
Given a metabolic network in terms of its metabolites and reactions, our goal is to efficiently compute the minimal knock out sets of reactions required to block a given behaviour....
Utz-Uwe Haus, Steffen Klamt, Tamon Stephen
BMCBI
2011
14 years 4 months ago
Properties of Metabolic Graphs: Biological Organization or Representation Artifacts?
Background: Standard graphs, where each edge links two nodes, have been extensively used to represent the connectivity of metabolic networks. It is based on this representation th...
Wanding Zhou, Luay Nakhleh
BIOCOMP
2009
14 years 11 months ago
Evolution of Domain Compositions in the Metabolic Networks of Human and Escherichia Coli
It is widely recognized that complexity of metabolic networks arises from duplication, recruitment and recombination of enzyme protein domains. However, variations of the domain ev...
Chen-Hsiang Yeang, Nils Baas
BMCBI
2010
113views more  BMCBI 2010»
14 years 10 months ago
Use of historic metabolic biotransformation data as a means of anticipating metabolic sites using MetaPrint2D and Bioclipse
Background: Predicting metabolic sites is important in the drug discovery process to aid in rapid compound optimisation. No interactive tool exists and most of the useful tools ar...
Lars Carlsson, Ola Spjuth, Samuel Adams, Robert C....