Background: Despite recent algorithmic and conceptual progress, the stoichiometric network analysis of large metabolic models remains a computationally challenging problem. Result...
Background: Biochemically detailed stoichiometric matrices have now been reconstructed for various bacteria, yeast, and for the human cardiac mitochondrion based on genomic and pr...
Scott A. Becker, Nathan D. Price, Bernhard O. Pals...
—This paper describes a new logic-based approach for representing and reasoning about metabolic networks. First it shows how biological pathways can be elegantly represented in a...
Background: Many attempts are being made to understand biological subjects at a systems level. A major resource for these approaches are biological databases, storing manifold inf...
Stephan Weise, Ivo Grosse, Christian Klukas, Dirk ...
Background: This paper considers the problem of identifying pathways through metabolic networks that relate to a specific biological response. Our proposed model, HME3M, first ide...