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BMCBI
2010
177views more  BMCBI 2010»
14 years 10 months ago
Modular composition predicts kinase/substrate interactions
Background: Phosphorylation events direct the flow of signals and metabolites along cellular protein networks. Current annotations of kinase-substrate binding events are far from ...
Yichuan Liu, Aydin Tozeren
BMCBI
2010
122views more  BMCBI 2010»
14 years 10 months ago
An automated framework for understanding structural variations in the binding grooves of MHC class II molecules
Background: MHC/HLA class II molecules are important components of the immune system and play a critical role in processes such as phagocytosis. Understanding peptide recognition ...
Kalidas Yeturu, Tapani Utriainen, Graham J. L. Kem...
BMCBI
2007
136views more  BMCBI 2007»
14 years 10 months ago
Genomorama: genome visualization and analysis
Background: The ability to visualize genomic features and design experimental assays that can target specific regions of a genome is essential for modern biology. To assist in the...
Jason D. Gans, Murray Wolinsky
BMCBI
2007
118views more  BMCBI 2007»
14 years 10 months ago
A new advance in alternative splicing databases: from catalogue to detailed analysis of regulation of expression and function of
Background: Most human genes produce several transcripts with different exon contents by using alternative promoters, alternative polyadenylation sites and alternative splice site...
Pierre de la Grange, Martin Dutertre, Margot Corre...
BMCBI
2008
116views more  BMCBI 2008»
14 years 10 months ago
A novel representation of RNA secondary structure based on element-contact graphs
Background: Depending on their specific structures, noncoding RNAs (ncRNAs) play important roles in many biological processes. Interest in developing new topological indices based...
Wenjie Shu, Xiaochen Bo, Zhiqiang Zheng, Shengqi W...