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» Reconstructing Subsets of Reals
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116
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BMCBI
2010
104views more  BMCBI 2010»
15 years 24 days ago
Parameters for accurate genome alignment
Background: Genome sequence alignments form the basis of much research. Genome alignment depends on various mundane but critical choices, such as how to mask repeats and which sco...
Martin C. Frith, Michiaki Hamada, Paul Horton
BMCBI
2007
130views more  BMCBI 2007»
15 years 24 days ago
A model-based optimization framework for the inference of regulatory interactions using time-course DNA microarray expression da
Background: Proteins are the primary regulatory agents of transcription even though mRNA expression data alone, from systems like DNA microarrays, are widely used. In addition, th...
Reuben Thomas, Carlos J. Paredes, Sanjay Mehrotra,...
123
Voted
BMCBI
2010
108views more  BMCBI 2010»
15 years 24 days ago
A genetic ensemble approach for gene-gene interaction identification
Background: It has now become clear that gene-gene interactions and gene-environment interactions are ubiquitous and fundamental mechanisms for the development of complex diseases...
Pengyi Yang, Joshua W. K. Ho, Albert Y. Zomaya, Bi...
100
Voted
BMCBI
2007
121views more  BMCBI 2007»
15 years 24 days ago
A constrained polynomial regression procedure for estimating the local False Discovery Rate
Background: In the context of genomic association studies, for which a large number of statistical tests are performed simultaneously, the local False Discovery Rate (lFDR), which...
Cyril Dalmasso, Avner Bar-Hen, Philippe Broët
109
Voted
BMCBI
2007
152views more  BMCBI 2007»
15 years 24 days ago
Difference-based clustering of short time-course microarray data with replicates
Background: There are some limitations associated with conventional clustering methods for short time-course gene expression data. The current algorithms require prior domain know...
Jihoon Kim, Ju Han Kim