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» Reconstructing the Topology of Protein Complexes
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112
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BMCBI
2008
139views more  BMCBI 2008»
15 years 16 days ago
A topological transformation in evolutionary tree search methods based on maximum likelihood combining p-ECR and neighbor joinin
Background: Inference of evolutionary trees using the maximum likelihood principle is NP-hard. Therefore, all practical methods rely on heuristics. The topological transformations...
Maozu Guo, Jian-Fu Li, Yang Liu
104
Voted
BMCBI
2008
144views more  BMCBI 2008»
15 years 16 days ago
Rule-based knowledge aggregation for large-scale protein sequence analysis of influenza A viruses
Background: The explosive growth of biological data provides opportunities for new statistical and comparative analyses of large information sets, such as alignments comprising te...
Olivo Miotto, Tin Wee Tan, Vladimir Brusic
111
Voted
BMCBI
2005
115views more  BMCBI 2005»
15 years 9 days ago
Statistical distributions of optimal global alignment scores of random protein sequences
Background: The inference of homology from statistically significant sequence similarity is a central issue in sequence alignments. So far the statistical distribution function un...
Hongxia Pang, Jiaowei Tang, Su-Shing Chen, Shiheng...
BMCBI
2005
100views more  BMCBI 2005»
15 years 9 days ago
Scoredist: A simple and robust protein sequence distance estimator
Background: Distance-based methods are popular for reconstructing evolutionary trees thanks to their speed and generality. A number of methods exist for estimating distances from ...
Erik L. L. Sonnhammer, Volker Hollich
EVOW
2010
Springer
15 years 7 months ago
Top-Down Induction of Phylogenetic Trees
We propose a novel distance based method for phylogenetic tree reconstruction. Our method is based on a conceptual clustering method that extends the well-known decision tree learn...
Celine Vens, Eduardo Costa, Hendrik Blockeel