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» Reconstructing the Topology of Protein Complexes
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81
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BMCBI
2010
150views more  BMCBI 2010»
14 years 10 months ago
MCL-CAw: a refinement of MCL for detecting yeast complexes from weighted PPI networks by incorporating core-attachment structure
Background: The reconstruction of protein complexes from the physical interactome of organisms serves as a building block towards understanding the higher level organization of th...
Sriganesh Srihari, Kang Ning, Hon Wai Leong
76
Voted
BMCBI
2010
132views more  BMCBI 2010»
14 years 10 months ago
Protein network prediction and topological analysis in Leishmania major as a tool for drug target selection
Background: Leishmaniasis is a virulent parasitic infection that causes a worldwide disease burden. Most treatments have toxic side-effects and efficacy has decreased due to the e...
Andrés F. Flórez, Daeui Park, Jong B...
SMA
2010
ACM
204views Solid Modeling» more  SMA 2010»
14 years 10 months ago
Topologically correct reconstruction of tortuous contour forests
Electrophysiological modeling of dendrites and other neurological processes is generally done in a simplified manner, by treating these structures as a series of cylinders (aka ca...
John Edwards, Chandrajit L. Bajaj
79
Voted
BMCBI
2007
202views more  BMCBI 2007»
14 years 10 months ago
ProtNet: a tool for stochastic simulations of protein interaction networks dynamics
Background: Protein interactions support cell organization and mediate its response to any specific stimulus. Recent technological advances have produced large data-sets that aim ...
Massimo Bernaschi, Filippo Castiglione, Alessandra...
JCB
2007
83views more  JCB 2007»
14 years 10 months ago
Evolutionary Networks in the Formatted Protein Sequence Space
In our recent work, a new approach to establish sequence relatedness, by walking through the protein sequence space, was introduced. The sequence space is built from 20 amino acid...
Zakharia M. Frenkel, Edward N. Trifonov