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» Reconstructing the Topology of Protein Complexes
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BMCBI
2010
150views more  BMCBI 2010»
13 years 6 months ago
MCL-CAw: a refinement of MCL for detecting yeast complexes from weighted PPI networks by incorporating core-attachment structure
Background: The reconstruction of protein complexes from the physical interactome of organisms serves as a building block towards understanding the higher level organization of th...
Sriganesh Srihari, Kang Ning, Hon Wai Leong
BMCBI
2010
132views more  BMCBI 2010»
13 years 6 months ago
Protein network prediction and topological analysis in Leishmania major as a tool for drug target selection
Background: Leishmaniasis is a virulent parasitic infection that causes a worldwide disease burden. Most treatments have toxic side-effects and efficacy has decreased due to the e...
Andrés F. Flórez, Daeui Park, Jong B...
SMA
2010
ACM
204views Solid Modeling» more  SMA 2010»
13 years 6 months ago
Topologically correct reconstruction of tortuous contour forests
Electrophysiological modeling of dendrites and other neurological processes is generally done in a simplified manner, by treating these structures as a series of cylinders (aka ca...
John Edwards, Chandrajit L. Bajaj
BMCBI
2007
202views more  BMCBI 2007»
13 years 6 months ago
ProtNet: a tool for stochastic simulations of protein interaction networks dynamics
Background: Protein interactions support cell organization and mediate its response to any specific stimulus. Recent technological advances have produced large data-sets that aim ...
Massimo Bernaschi, Filippo Castiglione, Alessandra...
JCB
2007
83views more  JCB 2007»
13 years 6 months ago
Evolutionary Networks in the Formatted Protein Sequence Space
In our recent work, a new approach to establish sequence relatedness, by walking through the protein sequence space, was introduced. The sequence space is built from 20 amino acid...
Zakharia M. Frenkel, Edward N. Trifonov