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» Reducing Gene Regulatory Networks by Decomposition
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BMCBI
2008
100views more  BMCBI 2008»
14 years 10 months ago
Extracting unrecognized gene relationships from the biomedical literature via matrix factorizations
Background: The construction of literature-based networks of gene-gene interactions is one of the most important applications of text mining in bioinformatics. Extracting potentia...
Hyunsoo Kim, Haesun Park, Barry L. Drake
CEC
2010
IEEE
14 years 5 months ago
Parameter estimation with term-wise decomposition in biochemical network GMA models by hybrid regularized Least Squares-Particle
High-throughput analytical techniques such as nuclear magnetic resonance, protein kinase phosphorylation, and mass spectroscopic methods generate time dense profiles of metabolites...
Prospero C. Naval, Luis G. Sison, Eduardo R. Mendo...
TSP
2010
14 years 4 months ago
Selection policy-induced reduction mappings for Boolean networks
Developing computational models paves the way to understanding, predicting, and influencing the long-term behavior of genomic regulatory systems. However, several major challenges ...
Ivan Ivanov, Plamen Simeonov, Noushin Ghaffari, Xi...
IEEEMM
2007
146views more  IEEEMM 2007»
14 years 10 months ago
Learning Microarray Gene Expression Data by Hybrid Discriminant Analysis
— Microarray technology offers a high throughput means to study expression networks and gene regulatory networks in cells. The intrinsic nature of high dimensionality and small s...
Yijuan Lu, Qi Tian, Maribel Sanchez, Jennifer L. N...
BMCBI
2010
97views more  BMCBI 2010»
14 years 10 months ago
Dual-functioning transcription factors in the developmental gene network of Drosophila melanogaster
Background: Quantitative models for transcriptional regulation have shown great promise for advancing our understanding of the biological mechanisms underlying gene regulation. Ho...
Denis C. Bauer, Fabian A. Buske, Timothy L. Bailey