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» Refactoring Methods for Knowledge Bases
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BIOINFORMATICS
2012
13 years 5 months ago
Epigenetic priors for identifying active transcription factor binding sites
Motivation Accurate knowledge of the genome-wide binding of transcription factors in a particular cell type or under a particular condition is necessary for understanding transcri...
Gabriel Cuellar-Partida, Fabian A. Buske, Robert C...
RECOMB
2005
Springer
16 years 3 months ago
Learning Interpretable SVMs for Biological Sequence Classification
Background: Support Vector Machines (SVMs) ? using a variety of string kernels ? have been successfully applied to biological sequence classification problems. While SVMs achieve ...
Christin Schäfer, Gunnar Rätsch, Sö...
135
Voted
BMCBI
2008
135views more  BMCBI 2008»
15 years 3 months ago
Knowledge-guided multi-scale independent component analysis for biomarker identification
Background: Many statistical methods have been proposed to identify disease biomarkers from gene expression profiles. However, from gene expression profile data alone, statistical...
Li Chen, Jianhua Xuan, Chen Wang, Ie-Ming Shih, Yu...
BMCBI
2008
110views more  BMCBI 2008»
15 years 3 months ago
Enhancing the prediction of protein pairings between interacting families using orthology information
Background: It has repeatedly been shown that interacting protein families tend to have similar phylogenetic trees. These similarities can be used to predicting the mapping betwee...
José M. G. Izarzugaza, David de Juan, Carle...
148
Voted
BMCBI
2007
105views more  BMCBI 2007»
15 years 3 months ago
Finding regulatory elements and regulatory motifs: a general probabilistic framework
Over the last two decades a large number of algorithms has been developed for regulatory motif finding. Here we show how many of these algorithms, especially those that model bind...
Erik van Nimwegen