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BMCBI
2010
227views more  BMCBI 2010»
14 years 9 months ago
Accurate and efficient gp120 V3 loop structure based models for the determination of HIV-1 co-receptor usage
Background: HIV-1 targets human cells expressing both the CD4 receptor, which binds the viral envelope glycoprotein gp120, as well as either the CCR5 (R5) or CXCR4 (X4) co-recepto...
Majid Masso, Iosif I. Vaisman
BMCBI
2010
156views more  BMCBI 2010»
14 years 9 months ago
Extended morphological processing: a practical method for automatic spot detection of biological markers from microscopic images
Background: A reliable extraction technique for resolving multiple spots in light or electron microscopic images is essential in investigations of the spatial distribution and dyn...
Yoshitaka Kimori, Norio Baba, Nobuhiro Morone
BMCBI
2008
175views more  BMCBI 2008»
14 years 9 months ago
Comprehensive inventory of protein complexes in the Protein Data Bank from consistent classification of interfaces
Background: Protein-protein interactions are ubiquitous and essential for all cellular processes. High-resolution X-ray crystallographic structures of protein complexes can reveal...
Andrew J. Bordner, Andrey A. Gorin
100
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CONSTRAINTS
2010
126views more  CONSTRAINTS 2010»
14 years 9 months ago
Lexicographically-ordered constraint satisfaction problems
Abstract. We describe a simple CSP formalism for handling multi-attribute preference problems with hard constraints, one that combines hard constraints and preferences so the two a...
Eugene C. Freuder, Robert Heffernan, Richard J. Wa...
BMCBI
2006
120views more  BMCBI 2006»
14 years 9 months ago
Integrating protein structures and precomputed genealogies in the Magnum database: Examples with cellular retinoid binding prote
Background: When accurate models for the divergent evolution of protein sequences are integrated with complementary biological information, such as folded protein structures, anal...
Michael E. Bradley, Steven A. Benner