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» Responses of Fluctuating Biological Systems
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BMCBI
2008
79views more  BMCBI 2008»
13 years 6 months ago
In silico docking of urokinase plasminogen activator and integrins
Background: Urokinase, its receptor and the integrins are functionally associated and involved in regulation of cell signaling, migration, adhesion and proliferation. No structura...
Bernard Degryse, Juan Fernández-Recio, Vale...
BMCBI
2006
130views more  BMCBI 2006»
13 years 6 months ago
An accurate and interpretable model for siRNA efficacy prediction
Background: The use of exogenous small interfering RNAs (siRNAs) for gene silencing has quickly become a widespread molecular tool providing a powerful means for gene functional s...
Jean-Philippe Vert, Nicolas Foveau, Christian Laja...
BMCBI
2007
167views more  BMCBI 2007»
13 years 6 months ago
A stochastic differential equation model for transcriptional regulatory networks
Background: This work explores the quantitative characteristics of the local transcriptional regulatory network based on the availability of time dependent gene expression data se...
Adriana Climescu-Haulica, Michelle D. Quirk
CIKM
2010
Springer
13 years 5 months ago
A hierarchical approach to reachability query answering in very large graph databases
The cost of reachability query computation using traditional algorithms such as depth first search or transitive closure has been found to be prohibitive and unacceptable in mass...
Saikat K. Dey, Hasan M. Jamil
BMCBI
2008
181views more  BMCBI 2008»
13 years 5 months ago
Assessing batch effects of genotype calling algorithm BRLMM for the Affymetrix GeneChip Human Mapping 500 K array set using 270
Background: Genome-wide association studies (GWAS) aim to identify genetic variants (usually single nucleotide polymorphisms [SNPs]) across the entire human genome that are associ...
Huixiao Hong, Zhenqiang Su, Weigong Ge, Leming M. ...