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WOSP
2010
ACM
15 years 2 months ago
Automatically improve software architecture models for performance, reliability, and cost using evolutionary algorithms
Quantitative prediction of quality properties (i.e. extrafunctional properties such as performance, reliability, and cost) of software architectures during design supports a syste...
Anne Martens, Heiko Koziolek, Steffen Becker, Ralf...
140
Voted
AI
2010
Springer
15 years 2 months ago
Soft arc consistency revisited
The Valued Constraint Satisfaction Problem (VCSP) is a generic optimization problem defined by a network of local cost functions defined over discrete variables. It has applicatio...
Martin C. Cooper, Simon de Givry, M. Sanchez, Thom...
111
Voted
BMCBI
2010
90views more  BMCBI 2010»
15 years 2 months ago
Local alignment of generalized k-base encoded DNA sequence
Background: DNA sequence comparison is a well-studied problem, in which two DNA sequences are compared using a weighted edit distance. Recent DNA sequencing technologies however o...
Nils Homer, Stanley F. Nelson, Barry Merriman
BMCBI
2010
105views more  BMCBI 2010»
15 years 2 months ago
A knowledge-guided strategy for improving the accuracy of scoring functions in binding affinity prediction
Background: Current scoring functions are not very successful in protein-ligand binding affinity prediction albeit their popularity in structure-based drug designs. Here, we propo...
Tiejun Cheng, Zhihai Liu, Renxiao Wang
BMCBI
2008
135views more  BMCBI 2008»
15 years 2 months ago
Inferring the role of transcription factors in regulatory networks
Background: Expression profiles obtained from multiple perturbation experiments are increasingly used to reconstruct transcriptional regulatory networks, from well studied, simple...
Philippe Veber, Carito Guziolowski, Michel Le Borg...
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