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» Routing betweenness centrality
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78
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BMCBI
2010
132views more  BMCBI 2010»
14 years 11 months ago
Protein network prediction and topological analysis in Leishmania major as a tool for drug target selection
Background: Leishmaniasis is a virulent parasitic infection that causes a worldwide disease burden. Most treatments have toxic side-effects and efficacy has decreased due to the e...
Andrés F. Flórez, Daeui Park, Jong B...
95
Voted
BMCBI
2007
127views more  BMCBI 2007»
14 years 11 months ago
Characterization of protein-interaction networks in tumors
Background: Analyzing differential-gene-expression data in the context of protein-interaction networks (PINs) yields information on the functional cellular status. PINs can be for...
Alexander Platzer, Paul Perco, Arno Lukas, Bernd M...
96
Voted
BMCBI
2007
148views more  BMCBI 2007»
14 years 11 months ago
Evaluation of gene-expression clustering via mutual information distance measure
Background: The definition of a distance measure plays a key role in the evaluation of different clustering solutions of gene expression profiles. In this empirical study we compa...
Ido Priness, Oded Maimon, Irad E. Ben-Gal
71
Voted
BMCBI
2010
88views more  BMCBI 2010»
14 years 11 months ago
Robust probabilistic superposition and comparison of protein structures
Background: Protein structure comparison is a central issue in structural bioinformatics. The standard dissimilarity measure for protein structures is the root mean square deviati...
Martin Mechelke, Michael Habeck
81
Voted
BMCBI
2010
126views more  BMCBI 2010»
14 years 11 months ago
GeneBrowser 2: an application to explore and identify common biological traits in a set of genes
Background: The development of high-throughput laboratory techniques created a demand for computer-assisted result analysis tools. Many of these techniques return lists of genes w...
Joel Arrais, João Fernandes, João Pe...