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82
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BMCBI
2010
146views more  BMCBI 2010»
15 years 27 days ago
On the Choice and Number of Microarrays for Transcriptional Regulatory Network Inference
Background: Transcriptional regulatory network inference (TRNI) from large compendia of DNA microarrays has become a fundamental approach for discovering transcription factor (TF)...
Elissa J. Cosgrove, Timothy S. Gardner, Eric D. Ko...
BMCBI
2010
224views more  BMCBI 2010»
15 years 27 days ago
An adaptive optimal ensemble classifier via bagging and rank aggregation with applications to high dimensional data
Background: Generally speaking, different classifiers tend to work well for certain types of data and conversely, it is usually not known a priori which algorithm will be optimal ...
Susmita Datta, Vasyl Pihur, Somnath Datta
120
Voted
BMCBI
2010
165views more  BMCBI 2010»
15 years 27 days ago
Filtering, FDR and power
Background: In high-dimensional data analysis such as differential gene expression analysis, people often use filtering methods like fold-change or variance filters in an attempt ...
Maarten van Iterson, Judith M. Boer, Renée ...
106
Voted
BMCBI
2007
123views more  BMCBI 2007»
15 years 27 days ago
Heritable clustering and pathway discovery in breast cancer integrating epigenetic and phenotypic data
Background: In order to recapitulate tumor progression pathways using epigenetic data, we developed novel clustering and pathway reconstruction algorithms, collectively referred t...
Zailong Wang, Pearlly Yan, Dustin P. Potter, Chari...
108
Voted
BMCBI
2008
114views more  BMCBI 2008»
15 years 27 days ago
Visualization of large influenza virus sequence datasets using adaptively aggregated trees with sampling-based subscale represen
Background: With the amount of influenza genome sequence data growing rapidly, researchers need machine assistance in selecting datasets and exploring the data. Enhanced visualiza...
Leonid Zaslavsky, Yiming Bao, Tatiana A. Tatusova