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» Sanitization models and their limitations
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BMCBI
2010
135views more  BMCBI 2010»
14 years 10 months ago
Delineation of amplification, hybridization and location effects in microarray data yields better-quality normalization
Background: Oligonucleotide arrays have become one of the most widely used high-throughput tools in biology. Due to their sensitivity to experimental conditions, normalization is ...
Marc Hulsman, Anouk Mentink, Eugene P. van Someren...
BMCBI
2010
117views more  BMCBI 2010»
14 years 10 months ago
Identification of NAD interacting residues in proteins
Background: Small molecular cofactors or ligands play a crucial role in the proper functioning of cells. Accurate annotation of their target proteins and binding sites is required...
Hifzur Rahman Ansari, Gajendra P. S. Raghava
BMCBI
2010
183views more  BMCBI 2010»
14 years 10 months ago
SING: Subgraph search In Non-homogeneous Graphs
Background: Finding the subgraphs of a graph database that are isomorphic to a given query graph has practical applications in several fields, from cheminformatics to image unders...
Raffaele Di Natale, Alfredo Ferro, Rosalba Giugno,...
BMCBI
2010
118views more  BMCBI 2010»
14 years 10 months ago
From learning taxonomies to phylogenetic learning: Integration of 16S rRNA gene data into FAME-based bacterial classification
Background: Machine learning techniques have shown to improve bacterial species classification based on fatty acid methyl ester (FAME) data. Nonetheless, FAME analysis has a limit...
Bram Slabbinck, Willem Waegeman, Peter Dawyndt, Pa...
BMCBI
2010
159views more  BMCBI 2010»
14 years 10 months ago
Predicting domain-domain interaction based on domain profiles with feature selection and support vector machines
Background: Protein-protein interaction (PPI) plays essential roles in cellular functions. The cost, time and other limitations associated with the current experimental methods ha...
Alvaro J. González, Li Liao