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» Scales and Scale-like Structures
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95
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BMCBI
2007
107views more  BMCBI 2007»
15 years 27 days ago
Prediction of potential drug targets based on simple sequence properties
Background: During the past decades, research and development in drug discovery have attracted much attention and efforts. However, only 324 drug targets are known for clinical dr...
Qingliang Li, Luhua Lai
118
Voted
BMCBI
2010
149views more  BMCBI 2010»
15 years 27 days ago
S3DB core: a framework for RDF generation and management in bioinformatics infrastructures
Background: Biomedical research is set to greatly benefit from the use of semantic web technologies in the design of computational infrastructure. However, beyond well defined res...
Jonas S. Almeida, Helena F. Deus, Wolfgang Maass
106
Voted
BMCBI
2007
99views more  BMCBI 2007»
15 years 27 days ago
Statistical significance of cis-regulatory modules
Background: It is becoming increasingly important for researchers to be able to scan through large genomic regions for transcription factor binding sites or clusters of binding si...
Dustin E. Schones, Andrew D. Smith, Michael Q. Zha...
127
Voted
BMCBI
2008
242views more  BMCBI 2008»
15 years 27 days ago
New time-scale criteria for model simplification of bio-reaction systems
Background: Quasi-steady state approximation (QSSA) based on time-scale analysis is known to be an effective method for simplifying metabolic reaction system, but the conventional...
Junwon Choi, Kyung-won Yang, Tai-yong Lee, Sang Yu...
111
Voted
BMCBI
2007
197views more  BMCBI 2007»
15 years 27 days ago
Boolean networks using the chi-square test for inferring large-scale gene regulatory networks
Background: Boolean network (BN) modeling is a commonly used method for constructing gene regulatory networks from time series microarray data. However, its major drawback is that...
Haseong Kim, Jae K. Lee, Taesung Park