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87
Voted
BMCBI
2007
119views more  BMCBI 2007»
15 years 25 days ago
Efficacy of different protein descriptors in predicting protein functional families
Background: Sequence-derived structural and physicochemical descriptors have frequently been used in machine learning prediction of protein functional families, thus there is a ne...
Serene A. K. Ong, Hong Huang Lin, Yu Zong Chen, Ze...
FDL
2004
IEEE
15 years 4 months ago
A Functional Programming Framework of Heterogeneous Model of Computation for System Design
System-on-Chip (SOC) and other complex distributed hardware/software systems contain heterogeneous components such as DSPs, micro-controllers, application specific logic etc., whi...
Deepak Mathaikutty, Hiren D. Patel, Sandeep K. Shu...
83
Voted
BMCBI
2010
105views more  BMCBI 2010»
15 years 28 days ago
A knowledge-guided strategy for improving the accuracy of scoring functions in binding affinity prediction
Background: Current scoring functions are not very successful in protein-ligand binding affinity prediction albeit their popularity in structure-based drug designs. Here, we propo...
Tiejun Cheng, Zhihai Liu, Renxiao Wang
103
Voted
BMCBI
2008
145views more  BMCBI 2008»
15 years 28 days ago
The contrasting properties of conservation and correlated phylogeny in protein functional residue prediction
Background: Amino acids responsible for structure, core function or specificity may be inferred from multiple protein sequence alignments where a limited set of residue types are ...
Jonathan R. Manning, Emily R. Jefferson, Geoffrey ...
BMCBI
2005
113views more  BMCBI 2005»
15 years 21 days ago
Alternative splicing and protein function
Background: Alternative splicing is a major mechanism of generating protein diversity in higher eukaryotes. Although at least half, and probably more, of mammalian genes are alter...
A. D. Neverov, Irena I. Artamonova, Ramil N. Nurtd...