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» Segment-based multiple sequence alignment
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BMCBI
2008
176views more  BMCBI 2008»
14 years 10 months ago
H2r: Identification of evolutionary important residues by means of an entropy based analysis of multiple sequence alignments
Background: A multiple sequence alignment (MSA) generated for a protein can be used to characterise residues by means of a statistical analysis of single columns. In addition to t...
Rainer Merkl, Matthias Zwick
ALMOB
2008
85views more  ALMOB 2008»
14 years 10 months ago
Noisy: Identification of problematic columns in multiple sequence alignments
Motivation: Sequence-based methods for phylogenetic reconstruction from (nucleic acid) sequence data are notoriously plagued by two effects: homoplasies and alignment errors. Larg...
Andreas W. M. Dress, Christoph Flamm, Guido Fritzs...
ICASSP
2010
IEEE
14 years 8 months ago
Multiple sequence alignment based bootstrapping for improved incremental word learning
We investigate incremental word learning with few training examples in a Hidden Markov Model (HMM) framework suitable for an interactive learning scenario with little prior knowle...
Irene Ayllól Clemente, Martin Heckmann, Ger...
BMCBI
2011
14 years 1 months ago
Protein alignment algorithms with an efficient backtracking routine on multiple GPUs
Background: Pairwise sequence alignment methods are widely used in biological research. The increasing number of sequences is perceived as one of the upcoming challenges for seque...
Jacek Blazewicz, Wojciech Frohmberg, Michal Kierzy...
BMCBI
2008
123views more  BMCBI 2008»
14 years 10 months ago
A tree-based conservation scoring method for short linear motifs in multiple alignments of protein sequences
Background: The structure of many eukaryotic cell regulatory proteins is highly modular. They are assembled from globular domains, segments of natively disordered polypeptides and...
Claudia Chica, Alberto Labarga, Cathryn M. Gould, ...