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» Segment-based multiple sequence alignment
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BMCBI
2008
142views more  BMCBI 2008»
14 years 9 months ago
Strategies for measuring evolutionary conservation of RNA secondary structures
Background: Evolutionary conservation of RNA secondary structure is a typical feature of many functional non-coding RNAs. Since almost all of the available methods used for predic...
Andreas R. Gruber, Stephan H. F. Bernhart, Ivo L. ...
BMCBI
2005
108views more  BMCBI 2005»
14 years 9 months ago
SplitTester: software to identify domains responsible for functional divergence in protein family
Background: Many protein families have undergone functional divergence after gene duplications such that current subgroups of the family carry out overlapping but distinct biologi...
Xiang Gao, Kent Vander Velden, Daniel F. Voytas, X...
BMCBI
2005
94views more  BMCBI 2005»
14 years 9 months ago
Measuring similarities between transcription factor binding sites
Background: Collections of transcription factor binding profiles (Transfac, Jaspar) are essential to identify regulatory elements in DNA sequences. Subsets of highly similar profi...
Szymon M. Kielbasa, Didier Gonze, Hanspeter Herzel
81
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BMCBI
2006
94views more  BMCBI 2006»
14 years 9 months ago
Novel knowledge-based mean force potential at the profile level
Background: The development and testing of functions for the modeling of protein energetics is an important part of current research aimed at understanding protein structure and f...
Qiwen Dong, Xiaolong Wang, Lei Lin
76
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BMCBI
2005
73views more  BMCBI 2005»
14 years 9 months ago
Evaluation of Glycine max mRNA clusters
Background: Clustering the ESTs from a large dataset representing a single species is a convenient starting point for a number of investigations into gene discovery, genome evolut...
Ronald L. Frank, Fikret Erçal