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BMCBI
2005
93views more  BMCBI 2005»
14 years 9 months ago
Two-part permutation tests for DNA methylation and microarray data
Background: One important application of microarray experiments is to identify differentially expressed genes. Often, small and negative expression levels were clipped-off to be e...
Markus Neuhäuser, Tanja Boes, Karl-Heinz J&ou...
BMCBI
2008
135views more  BMCBI 2008»
14 years 9 months ago
Identification of a small optimal subset of CpG sites as bio-markers from high-throughput DNA methylation profiles
Background: DNA methylation patterns have been shown to significantly correlate with different tissue types and disease states. High-throughput methylation arrays enable large-sca...
Hailong Meng, Edward Lenn Murrelle, Guoya Li
BMCBI
2008
128views more  BMCBI 2008»
14 years 9 months ago
Improving the prediction accuracy in classification using the combined data sets by ranks of gene expressions
Background: The information from different data sets experimented under different conditions may be inconsistent even though they are performed with the same research objectives. ...
Ki-Yeol Kim, Dong Hyuk Ki, Hei-Cheul Jeung, Hyun C...
BMCBI
2010
158views more  BMCBI 2010»
14 years 9 months ago
Validation of differential gene expression algorithms: Application comparing fold-change estimation to hypothesis testing
Background: Sustained research on the problem of determining which genes are differentially expressed on the basis of microarray data has yielded a plethora of statistical algorit...
Corey M. Yanofsky, David R. Bickel
BMCBI
2008
115views more  BMCBI 2008»
14 years 9 months ago
Probe signal correction for differential methylation hybridization experiments
Background: Non-biological signal (or noise) has been the bane of microarray analysis. Hybridization effects related to probe-sequence composition and DNA dye-probe interactions h...
Dustin P. Potter, Pearlly Yan, Tim Hui-Ming Huang,...