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» Selection of optimal reference genes for normalization in qu...
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73
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BMCBI
2010
106views more  BMCBI 2010»
14 years 10 months ago
Selection of optimal reference genes for normalization in quantitative RT-PCR
Background: Normalization in real-time qRT-PCR is necessary to compensate for experimental variation. A popular normalization strategy employs reference gene(s), which may introdu...
Inna Chervoneva, Yanyan Li, Stephanie Schulz, Sean...
70
Voted
BMCBI
2004
127views more  BMCBI 2004»
14 years 10 months ago
Optimized LOWESS normalization parameter selection for DNA microarray data
Background: Microarray data normalization is an important step for obtaining data that are reliable and usable for subsequent analysis. One of the most commonly utilized normaliza...
John A. Berger, Sampsa Hautaniemi, Anna-Kaarina J&...
73
Voted
BMCBI
2006
98views more  BMCBI 2006»
14 years 10 months ago
Quantitative comparison of EST libraries requires compensation for systematic biases in cDNA generation
Background: Publicly accessible EST libraries contain valuable information that can be utilized for studies of tissue-specific gene expression and processing of individual genes. ...
Donglin Liu, Joel H. Graber
BMCBI
2008
124views more  BMCBI 2008»
14 years 10 months ago
A probe-treatment-reference (PTR) model for the analysis of oligonucleotide expression microarrays
Background: Microarray pre-processing usually consists of normalization and summarization. Normalization aims to remove non-biological variations across different arrays. The norm...
Huanying Ge, Chao Cheng, Lei M. Li
102
Voted
BMCBI
2004
128views more  BMCBI 2004»
14 years 10 months ago
Comparing transformation methods for DNA microarray data
Background: When DNA microarray data are used for gene clustering, genotype/phenotype correlation studies, or tissue classification the signal intensities are usually transformed ...
Helene H. Thygesen, Aeilko H. Zwinderman