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» Sequence Complexity for Biological Sequence Analysis
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86
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BMCBI
2007
78views more  BMCBI 2007»
15 years 23 days ago
Improved human disease candidate gene prioritization using mouse phenotype
Background: The majority of common diseases are multi-factorial and modified by genetically and mechanistically complex polygenic interactions and environmental factors. High-thro...
Jing Chen, Huan Xu, Bruce J. Aronow, Anil G. Jegga
79
Voted
BMCBI
2007
88views more  BMCBI 2007»
15 years 26 days ago
Use of DNA melting simulation software for in silico diagnostic assay design: targeting regions with complex melting curves and
Background: DNA melting curve analysis using double-stranded DNA-specific dyes such as SYTO9 produce complex and reproducible melting profiles, resulting in the detection of multi...
John P. Rasmussen, Christopher P. Saint, Paul T. M...
82
Voted
BMCBI
2008
111views more  BMCBI 2008»
15 years 26 days ago
GENOMEPOP: A program to simulate genomes in populations
Background: There are several situations in population biology research where simulating DNA sequences is useful. Simulation of biological populations under different evolutionary...
Antonio Carvajal-Rodríguez
107
Voted
RECOMB
2003
Springer
16 years 1 months ago
Transforming men into mice: the Nadeau-Taylor chromosomal breakage model revisited
Although analysis of genome rearrangements was pioneered by Dobzhansky and Sturtevant 65 years ago, we still know very little about the rearrangement events that produced the exis...
Pavel A. Pevzner, Glenn Tesler
115
Voted
BMCBI
2007
149views more  BMCBI 2007»
15 years 23 days ago
SAMPI: Protein Identification with Mass Spectra Alignments
Background: Mass spectrometry based peptide mass fingerprints (PMFs) offer a fast, efficient, and robust method for protein identification. A protein is digested (usually by tryps...
Hans-Michael Kaltenbach, Andreas Wilke, Sebastian ...