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» Sequence Database Search Using Jumping Alignments
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BMCBI
2005
115views more  BMCBI 2005»
14 years 10 months ago
Statistical distributions of optimal global alignment scores of random protein sequences
Background: The inference of homology from statistically significant sequence similarity is a central issue in sequence alignments. So far the statistical distribution function un...
Hongxia Pang, Jiaowei Tang, Su-Shing Chen, Shiheng...
98
Voted
WABI
2004
Springer
106views Bioinformatics» more  WABI 2004»
15 years 3 months ago
Suboptimal Local Alignments Across Multiple Scoring Schemes
Abstract. Sequence alignment algorithms have a long standing tradition in bioinformatics. In this paper, we formulate an extension to existing local alignment algorithms: local ali...
Morris Michael, Christoph Dieterich, Jens Stoye
RECOMB
1998
Springer
15 years 2 months ago
Alignments without low-scoring regions
Given a strong match between regions of two sequences, how far can the match be meaningfully extended if gaps are allowed in the resulting alignment? The aim is to avoid searching...
Zheng Zhang 0004, Piotr Berman, Webb Miller
JCB
2007
106views more  JCB 2007»
14 years 10 months ago
Clustered Sequence Representation for Fast Homology Search
We present a novel approach to managing redundancy in sequence databanks such as GenBank. We store clusters of near-identical sequences as a representative union-sequence and a se...
Michael Cameron, Yaniv Bernstein, Hugh E. Williams
BIBE
2005
IEEE
126views Bioinformatics» more  BIBE 2005»
15 years 3 months ago
Highly Scalable and Accurate Seeds for Subsequence Alignment
We propose a method for finding seeds for the local alignment of two nucleotide sequences. Our method uses randomized algorithms to find approximate seeds. We present a dynamic ...
Abhijit Pol, Tamer Kahveci