151 search results - page 2 / 31 » Sequence variation in ligand binding sites in proteins |
103
click to vote
BIOCOMP
2008
15 years 1 months ago
2008
Computational analyses of protein structure-function relationships have traditionally been based on sequence homology, fold family analysis and 3D motifs/templates. Previous struct...
106
click to vote
BMCBI
2007
14 years 11 months ago
2007
Background: An accurate description of protein shape derived from protein structure is necessary to establish an understanding of protein-ligand interactions, which in turn will l...
113
click to vote
BMCBI
2007
14 years 12 months ago
2007
Background: Since many of the new protein structures delivered by high-throughput processes do not have any known function, there is a need for structure-based prediction of prote...
110
click to vote
BMCBI
2007
14 years 11 months ago
2007
Background: For many metalloproteins, sequence motifs characteristic of metal-binding sites have not been found or are so short that they would not be expected to be metal-specifi...
BMCBI
2005
14 years 11 months ago
2005
Background: The functional sites of a protein present important information for determining its cellular function and are fundamental in drug design. Accordingly, accurate methods...