Although snake venom proteins have been proven instrumental in the design of blood clotting and cytostatic breast cancer drugs, the main method in use to sequence these unknown pr...
Background: High-resolution tandem mass spectra can now be readily acquired with hybrid instruments, such as LTQ-Orbitrap and LTQ-FT, in high-throughput shotgun proteomics workflo...
Chongle Pan, Byung-Hoon Park, William H. McDonald,...
Background: Analysis of complex samples with tandem mass spectrometry (MS/MS) has become routine in proteomic research. However, validation of database search results creates a bo...
The protein inference problem represents a major challenge in shotgun proteomics. Here we describe a novel Bayesian approach to address this challenge that incorporates the predict...
Yong Fuga Li, Randy J. Arnold, Yixue Li, Predrag R...
We study the shape of coverage functions resulting from the sequencing of random genome fragments, and show that they can be described by Galton-Watson trees. This extends standar...