Cluster methods have been successfully applied in gene expression data analysis to address tumor classification. By grouping tissue samples into homogeneous subsets, more systema...
Encouraging exploration, typically by preserving the diversity within the population, is one of the most common method to improve the behavior of evolutionary algorithms with dece...
Background: Structural variations caused by a wide range of physico-chemical and biological sources directly influence the function of a protein. For enzymatic proteins, the struc...
Drew H. Bryant, Mark Moll, Brian Y. Chen, Viachesl...
Background: The presence of gaps in an alignment of nucleotide or protein sequences is often an inconvenience for bioinformatical studies. In phylogenetic and other analyses, for ...
Rodrigo Gouveia-Oliveira, Peter Wad Sackett, Ander...
Background: Many molecules are flexible and undergo significant shape deformation as part of their function, and yet most existing molecular shape comparison (MSC) methods treat t...