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» Simulating the Hallmarks of Cancer
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CEC
2010
IEEE
15 years 6 months ago
Accelerated optimisation of chemotherapy dose schedules using fitness inheritance
Abstract-- Cancer treatment by chemotherapy involves multiple applications of toxic drugs over a period of time. Optimising the schedule of these treatments can improve the outcome...
Robert Barbour, David W. Corne, John A. W. McCall
BIOSYSTEMS
2008
72views more  BIOSYSTEMS 2008»
15 years 5 months ago
The manipulation of calcium oscillations by harnessing self-organisation
This paper investigates how self-organisation might be harnessed for the manipulation and control of calcium oscillations. Calcium signalling mechanisms are responsible for a numb...
Cristina Costa Santini, Andy M. Tyrrell
EJASP
2010
132views more  EJASP 2010»
15 years 1 days ago
Uncovering Transcriptional Regulatory Networks by Sparse Bayesian Factor Model
The problem of uncovering transcriptional regulation by transcription factors (TFs) based on microarray data is considered. A novel Bayesian sparse correlated rectified factor mod...
Jia Meng, Jianqiu Zhang, Yuan (Alan) Qi, Yidong Ch...
APVIS
2009
15 years 6 months ago
Visualization of signal transduction processes in the crowded environment of the cell
In this paper, we propose a stochastic simulation to model and analyze cellular signal transduction. The high number of objects in a simulation requires advanced visualization tec...
Martin Falk, Michael Klann, Matthias Reuss, Thomas...
BMCBI
2007
104views more  BMCBI 2007»
15 years 5 months ago
Comparative evaluation of gene-set analysis methods
Background: Multiple data-analytic methods have been proposed for evaluating gene-expression levels in specific biological pathways, assessing differential expression associated w...
Qi Liu, Irina Dinu, Adeniyi J. Adewale, John D. Po...