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105
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BMCBI
2006
116views more  BMCBI 2006»
15 years 19 days ago
Optimized mixed Markov models for motif identification
Background: Identifying functional elements, such as transcriptional factor binding sites, is a fundamental step in reconstructing gene regulatory networks and remains a challengi...
Weichun Huang, David M. Umbach, Uwe Ohler, Leping ...
97
Voted
BMCBI
2007
101views more  BMCBI 2007»
15 years 18 days ago
Robust detection and verification of linear relationships to generate metabolic networks using estimates of technical errors
Background: The size and magnitude of the metabolome, the ratio between individual metabolites and the response of metabolic networks is controlled by multiple cellular factors. A...
Frank Kose, Jan Budczies, Matthias Holschneider, O...
126
Voted
BMCBI
2005
107views more  BMCBI 2005»
15 years 14 days ago
A stepwise framework for the normalization of array CGH data
Background: In two-channel competitive genomic hybridization microarray experiments, the ratio of the two fluorescent signal intensities at each spot on the microarray is commonly...
Mehrnoush Khojasteh, Wan L. Lam, Rabab Kreidieh Wa...
95
Voted
BMCBI
2005
90views more  BMCBI 2005»
15 years 14 days ago
An algorithm for the determination and quantification of components of nucleic acid mixtures based on single sequencing reaction
Background: Determination and quantification of nucleic acid components in a mixture is usually accomplished by microarray approaches, where the mixtures are hybridized against sp...
Alexander E. Pozhitkov, Kathryn Stemshorn, Diethar...
104
Voted
BMCBI
2005
97views more  BMCBI 2005»
15 years 14 days ago
Modelling the correlation between the activities of adjacent genes in drosophila
Background: Correlation between the expression levels of genes which are located close to each other on the genome has been found in various organisms, including yeast, drosophila...
Helene H. Thygesen, Aeilko H. Zwinderman